Association between obesity and cardiovascular disease in elderly patients with diabetes: A retrospective cohort study
Journal of Clinical Endocrinology and Metabolism Oct 07, 2021
Hong S, Park JH, Han K, et al. - Among elderly patients with diabetes, body mass index (BMI) was identified as an inadequate risk indicator for outcomes associated with obesity but waist circumference (WC) afforded an appropriate alternative.
In this retrospective observational study with a mean follow-up of 7.26 years, a total of 249,903 elderly (≥65 years) patients with type 2 diabetes mellitus and no pre-existing cardiovascular disease were included.
The primary outcome (a composite of stroke, myocardial infarction, and all-cause death) risk had an L-shaped and a U-shaped link with BMI and WC, respectively.
Multivariable Cox proportional hazard models showed a lower risk of primary composite outcomes in the highest BMI group (≥30 kg/m 2; hazards ratio [HR]=0.824) vs in the normal BMI group (≥18.5 and <23 kg/m 2).
The risk was higher in the highest WC group (≥100 cm/≥95 cm; men/women; HR=1.434) vs the normal WC group (<90 cm/<85 cm; men/women).
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty
-
Paid Market Research Surveys
-
Case discussions, News & Journals' summaries