Trinh NTH, Bruckner TA, Lemaitre M, et al. - Using national antibiotic dispensation data in French children from January 2009 to December 2017 (IQVIA Suivi de la Dispensation Médicale database), researchers performed an interrupted time–series analysis to ascertain if updated clinical practice guidelines for managing upper respiratory tract infections released in France in November 2011 were correlated with changes in national outpatient pediatric antibiotic use. One hundred twenty-three million pediatric antibiotic prescriptions were analyzed. Amoxicillin was the most commonly prescribed individual antibiotic agent. At the national level, the 2011 guidelines for upper respiratory tract infections preceded changes in outpatient pediatric antibiotic use, with a replacement of broad-spectrum antibiotics by amoxicillin.