Vu CN, Lewis CM, Bailard NS, et al. - Researchers here examined if and how the administration of oral celecoxib, gabapentin, and/or tramadol hydrochloride before surgery is associated with perioperative opioid requirements in patients undergoing head and neck surgery with free flap reconstruction. In addition, they determined if multimodal analgesia (MMA) affects the duration of stay in the postanesthesia care unit (PACU). They conducted a retrospective case-control study of 149 patients who received oral celecoxib, gabapentin, and/or tramadol medications before surgery and 208 patients who did not. Outcomes suggest that patients who received the medications had reduction in opioid use and the duration of stay in the PACU. This suggests that the use of a multimodal analgesia regimen, such as celecoxib, gabapentin, and/or tramadol, may result in reduction in opioid use during the perioperative period and shortening in the duration of stay in the PACU.