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Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse

International Journal of Rheumatic Diseases Feb 06, 2020

Glinatsi D, Brahe CH, Hetland ML, et al. - Researchers intended to evaluate whether magnetic resonance imaging (MRI) pathologies in the wrist/hand of rheumatoid arthritis (RA) patients are correlated with patient-reported outcomes (PROs) at clinical remission and relapse. Before tapering their biologic disease-modifying antirheumatic drugs, wrist/hand MRIs and wrists/hands/feet radiographs were collected in 114 established RA individuals in clinical remission. According to the Outcome Measures, MRIs were evaluated in Rheumatology (OMERACT) RA MRI score (RAMRIS) for inflammation (synovitis/tenosynovitis/bone marrow edema) and damage (bone erosion/joint space narrowing) at baseline (ie remission) and in case of relapse (n = 70). At baseline, radiographs were estimated according to the Sharp/van der Heijde (SvH) method. The data indicated that magnetic resonance imaging-assessed wrist/hand damage, but not inflammation, in individuals with established RA is correlated with patient-reported physical impairment at remission and relapse. In addition, the amount of damage in the wrist/hand is correlated with decreased hand function.
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