Association between mean arterial pressure and acute kidney injury and a composite of myocardial injury and mortality in postoperative critically ill patients: A retrospective cohort analysis
Critical Care Medicine Jun 20, 2019
Khanna AK, et al. - Using a retrospective cohort design, researchers performed a study on postoperative patients (n=2,833) admitted to the surgical ICU to investigate the link between hypotension and a composite of myocardial injury (troponin T ≥ 0.03 ng/mL without nonischemic cause) and mortality up to 7 postoperative days. Acute kidney injury (creatinine concentration ≥ 0.3 mg/dL or 1.5 times baseline) was also considered secondarily. In postoperative critical care patients, a strong association of increasing hypotension (defined by lowest mean arterial pressures per day) with myocardial injury, mortality, and renal injury was evident. With an adjusted hazard ratio of 1.27, an increase was noted in the acute kidney injury risk over a range of minimum daily pressures from 110 mmHg to 50 mm Hg.
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