Øyen N, et al. - Using the DNBC (Danish National Birth Cohort), 1996–2003, and MoBa (Norwegian Mother and Child Cohort Study), 2000–2009, researchers examined the link between maternal folic acid supplementation during early pregnancy and risk of congenital heart defects in offspring. Heart defects were detected in 2,247 individuals among 197,123 births. The adjusted relative risks of heart defects for periconceptional (4 weeks before through 8 weeks after conception) use of folic acid plus other supplements (54.8%), folic acid only (12.2%), and non–folic acid supplements (5.0%) vs no supplement use (28.0%), were 0.99, 1.08, and 1.07, respectively. Overall, no link was found between folic acid supplementation and offspring risk of heart defects.