Haugen CE, McAdams-DeMarco M, Verna EC, et al. - In this cohort study done at nine liver transplant centers in the United States from March 1, 2012, to May 1, 2018, among 1,108 adult liver transplant candidates without hepatocellular carcinoma, researchers sought to assess whether the relationship between wait-list mortality and frailty differed by BMI of liver transplant candidates. Frailty was related to a twice greater risk of wait-list mortality among nonobese liver transplant candidates and candidates with class 1 obesity. Nevertheless, the mortality risk correlated with frailty varied for candidates with class 2 or greater obesity, with frail candidates having more than the threefold greater risk of wait-list mortality in comparison with nonfrail patients. Frailty evaluations may aid to recognize vulnerable patients, especially those with a BMI of 35.0 or more, in whom a clinician’s visual assessment may be less competent to evaluate muscle mass and nutritional status.