Wang AM, et al. - In patients with laryngopharyngeal reflux disease (LPRD), researchers evaluated autonomic nerve function and determined the association between LPRD and autonomic nerve dysfunction. Using the reflux symptom index (RSI) and reflux finding score (RFS) scales, patients with suspected LPRD who visited the outpatient department were evaluated. Using 5-min short-range heart rate variability, 81 suspected LPRD patients with RSI > 13 and RFS > 7 were examined and all received diagnostic proton pump inhibitor treatment. Among patients with LPRD, autonomic nerve dysfunction was noted. LPRD severity has been significantly associated with autonomic nerve dysfunction and negatively linked to vagal nerve function.