Park J, Shin DW, Han K, et al. - Researchers sought to determine if elevated risk of kidney cancer exists in relation to chronic kidney disease at milder stages. For this purpose, they used a retrospective cohort consisting of 9,809,317 adults in Republic of Korea who took part in a nationwide health screening (2009–2016). Following adjustment for multiple confounders, an elevated risk of kidney cancer was observed in relation to reduced estimated glomerular filtration rate (eGFR) vs participants with eGFR of 60-89mL/min/1.73m ² . There was a dose-response association between the severity of proteinuria and incident renal cancer. Findings demonstrated a significant link of decreased eGFR as well as proteinuria with subsequent risk of kidney cancer, likely in a synergistic manner.