Grau-Rivera O, Operto G, Falcón C, et al. - Researchers examined cognitively unimpaired adults at increased risk for Alzheimer’s disease (AD) with insomnia for their cognitive performance and brain structural pattern. From the ALFA (ALzheimer and FAmilies) study, they assessed 1,683 cognitively unimpaired middle/late-middle-aged adults who underwent neuropsychological assessment, T1-weighted structural imaging (n = 366), and diffusion-weighted imaging (n = 334) in this cross-sectional study. Six hundred fifteen out of 1,683 participants (36.5%) reported insomnia; these included 137 out of 366 (37.4%) with T1-weighted structural imaging available and 119 out of 334 (35.6%) with diffusion-weighted imaging. The analysis revealed an association of insomnia in these adults with poorer performance in some executive functions and volume changes in cortical and subcortical gray matter, including key areas implicated in Alzheimer’s disease, as well as reduced white matter diffusivity.