Association between infection and thrombosis after coronary artery bypass grafting: A cohort study
Journal of Cardiothoracic and Vascular Anesthesia Feb 28, 2019
Liu X, et al. - In this retrospective cohort study performed at a single institution, researchers examined all patients who had coronary artery bypass grafting (CABG) in order to assess the association of postoperative infection with thrombosis and major adverse cardiovascular and cerebral events (MACCEs) in these subjects. Based on the presence or absence of infection, two groups of patients were defined. Overall 75 patients who experienced infection and 2,926 control patients were included. Factors that conferred risk for infection were: older age, higher level of creatinine, chronic lung disease, cardiopulmonary bypass time, aortic cross-clamp time, history of renal failure, cardiopulmonary bypass, left ventricular assist device or intra-aortic balloon pump, length of stay in the intensive care unit, and duration of tracheal intubation. By 5.132-fold increased odds of perioperative thrombosis were noted in relation to the presence of infection, compared with control. However, there was no link between infection and a significant increase in MACCEs. A significant increase in MACCEs was noted in relation to age.
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