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Association between hypertensive disorders of pregnancy and neurodevelopmental outcomes among offspring

JAMA Mar 31, 2021

Brand JS, Lawlor DA, Larsson H, et al. - Researchers conducted this Swedish register-based study with the aim to determine if hypertensive disorders of pregnancy (HDP) are linked with poorer neurodevelopmental outcomes in offspring independently of shared familial confounding factors. For this cohort study, they utilized data from a birth cohort divided into 1,085,024 individuals born between 1987 and 1996 and followed up until December 31, 2014, and 285 ,901 men born between 1982 and 1992 who attended assessments for military conscription, including a cognitive function test. Findings suggested a somewhat higher incidence of autism spectrum disorders (ASDs), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability (ID) and slightly lower overall cognitive performance among offspring of HDP-complicated pregnancies. Analyses comparing siblings had less statistical power and suggested links of a similar magnitude with ASDs and possibly ADHD only. Per findings, HDP are linked with modestly raised risks of ASDs and possibly ADHD in offspring, whereas correlations with ID and cognitive performance appear to be because of confounding by shared familial characteristics.

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