Redfors B, Chen S, Ben-Yehuda O, et al. - Since a greater tendency for reactive platelets to cause thrombosis may be seen in the presence of hypertension-induced vascular and endothelial dysfunction, researchers determined if patients with hypertension vs those without carry different risk of major adverse cardiac events (MACE) following percutaneous coronary intervention (PCI) among a sample of patients with on-clopidogrel residual high platelet reactivity (HPR). In this prospective, multicenter registry, the ADAPT-DES, they included patients effectively treated with coronary drug-eluting stents (DES). Older age, higher likelihood of having other cardiovascular risk factors, and higher P2Y12 reaction units, were observed among patients with hypertension vs those without hypertension. Findings revealed increased 2-year MACE rates after successful PCI with DES in patients with both hypertension and residual HPR on clopidogrel. Among patients with hypertension, a greater influence of HPR on the risk of adverse events was observed vs those without hypertension.