Jurčić V, et al. - In the affected skin of 70 adult subjects with immunoglobulin A vasculitis (IgAV), researchers examined the connection between histopathologic changes and expression profiles of 14 miRNAs. Altered miRNA expression, particularly miRNA-223-3p, can associate with the skin inflammatory state in IgAV. Most of the aberrantly expressed miRNAs in IgAV-affected skin are known to influence the signalling pathway of NF-κB, which is crucial to the activation of key pro-inflammatory genes, including TNF-α, IL-6 and IL-8. In addition, miR-146a-5p and miR-148b-3p, inflammatory gene expression negative regulators, showed reduced expression and could contribute to exaggerated inflammation. Further investigation of miRNAs expression in affected tissues may enhance knowledge of IgAV pathogenesis and may help identify novel biomarkers in body fluids.