Lin MS, et al. - In this community-based, cross-sectional study, researchers examined the influence of hepatitis C virus (HCV) seropositivity on menopausal bone mineral density (BMD) loss. An HCV seropositivity rate of 32.2% was noted among 636 menopausal women (aged 45–80 years) who underwent annual health checks in two rural townships in Yunlin County, Taiwan. Compared to the seronegative individuals, the HCV-seropositive participants displayed significantly lower BMD in different anatomic locations and had higher rates of major osteoporotic fractures and hip fractures. This suggests HCV infection could be an independent risk factor for menopausal BMD loss and fractures predicted by fracture risk assessment tool (FRAX).