Guo Y, Rist PM, Sabater-Lleal M, et al. - Researchers sought to examine potential causal relationships between hemostatic measures and migraine susceptibility using genetic instrumental analysis. Using available genome-wide association study (GWAS) summary statistics, two-sample Mendelian randomization instrumental analyses were applied to hemostatic measures as potentially causal for migraine and its subtypes, migraine with aura (MA) and migraine without aura (MO). Twelve blood-based hemostasis measures were investigated, including plasma levels or activity of 8 hemostatic factors and 2 fibrinopeptides, as well as 2 hemostasis clinical tests. Increased coagulation factor VIII activity, von Willebrand factor level, and phosphorylated fibrinopeptide A level were found to have significant instrumental effects on migraine susceptibility. The findings support the potential causality of increased FVIII, vWF, and phosphorylated fibrinopeptide A, as well as decreased fibrinogen, in migraine susceptibility, particularly in MA, potentially exhibiting etiologic connections between hemostasis and migraine.