Wang Z, Liu Y, Xie J, et al. - In a general population free from cardiovascular disease (CVD), a significant predictor of subclinical myocardial injury (SC-MI) was hemoglobin glycation index (HGI).

• A study of 6,009 participants free of CVD from the third National Health and Nutrition Examination Survey, to investigate the association between HGI and SC-MI in the general population free from CVD.

• Individuals with SC-MI exhibited significantly higher HGI vs those without, and there was a positive correlation of HGI with SC-MI as well as with other metabolic disorder parameters.

• Each 1-unit increment of HGI and glycated hemoglobin A1c (HbA1c) was independently related to higher risk of SC-MI, while fasting plasma glucose (FPG) lost predictive ability for SC-MI with the increase of confounding factors [OR (95% CI): 1.001].

• Subgroup analysis revealed independent association of HGI with higher risk of SC-MI only in participants without diabetes, while there was no independent predictive role of HbA1c and FPG in both diabetic and non-diabetic individuals.