Peterson M, et al. - The association between HbA_1c and sural nerve function was investigated in a group of people with normal glucose tolerance, impaired glucose tolerance or Type 2 diabetes. At all levels of HbA_1c, the clinicians found a relationship between sural nerve amplitude and HbA_1c. As per findings, reduced amplitude was more pronounced than was decreased conduction velocity, supporting the notion that axonal degeneration was an earlier and more prominent effect of hyperglycaemia compared to demyelination.