Wang L, et al. - In this cross-sectional study, researchers ascertained if there was a discrepancy between 237 postmenopausal women with type 2 diabetes mellitus (T2DM) and 93 non-diabetic women in the levels of bone biochemical markers and investigated the correlation between the level of glycosylated hemoglobin A1c (HbA1c) and bone biochemical markers in these subjects. By one-way ANOVA or chi-square test, the differences in the levels of bone biochemical markers between patients and controls were analyzed. By multivariate regression, forest plot and fitted curve, the link between HbA1c and bone biochemical markers were analyzed. In postmenopausal women with T2DM, bone formation was inhibited, but bone resorption was not affected and poor glycemic control was associated with lower levels of bone formation, and the risk of bone fracture in postmenopausal women with T2DM might increase. There was no significant association between HbA1c and other biochemical markers.