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Association between glutathione S-transferase (GST) polymorphisms and schizophrenia in a Chinese Han population

Neuropsychiatric Disease and Treatment Feb 24, 2020

Yan C, Duan L, Fu C, et al. - Researchers conducted a case-control study with the aim to determine whether there is an association between genetic polymorphisms in GST and schizophrenia (SCZ) in the Chinese Han population. They performed genotyping in a total of 794 participants [379 SCZ patients (case group) and 415 healthy individuals (control group)] by polymerase chain reaction-restriction fragment length for polymorphisms in GST genes. Relative to the control group, the case group exhibited a higher frequency of the GSTM1 null genotype as well as a higher frequency of the GSTM1 and GSTT1 double null genotype. Outcomes suggest a possible relation of the GSTM1 null genotype and the GSTM1 and GSTT1 double null genotype with the onset of SCZ in the Chinese Han population.
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