Silva-Ramirez B, Macías-González EJ, Frausto-Valdes OS, et al. - Variants rs16901979, rs1447295, and 7837328 at 8q24 locus were found to be associated with the susceptibility for developing prostate cancer (PCa) among Mexican men, as confirmed for the first time ever in this study.

• This is a case-control analysis of 326 men with PCa, and 549 non-PCa men (88 with benign prostatic hyperplasia BPH and 461 healthy controls).

• On comparing PCa patients against controls, links of the rs16901979, rs1447295, and rs7837328 SNPs with PCa were evident (OR = 2.8, 1.8, and 1.72, respectively), under different inheritance models.

• This link continued between PCa and BPH patients under distinct models (OR = 8.5, 2.2, and 1.9, respectively).

• The integrated impact of the alleles CGAA for the SNPs rs16901979, rs6983267, rs1447295, and rs7837328 demonstrated significant differences between PCa cases and controls (OR = 2.9).

• There were no associations of four 8q24 variants with D’Amico score, age at diagnosis, and bone metastases.