Andersson NW, et al. - For this cohort study, researchers obtained individual-level pregnancy data from various nationwide registries in Denmark from the study period of January 1, 1997, through December 31, 2016, resulting in a cohort of 1,650,649 pregnancies in order to examine the correlation between local podophyllotoxin exposure during pregnancy and risk of adverse fetal outcomes. A total of 9,229 pregnancies for the analyses of major birth defects and 18,590 pregnancies for the analyses of spontaneous abortions were involved in this study. Among the podophyllotoxin-exposed pregnancies, 29 infants were diagnosed with major birth defects, contrasted with 286 among the unexposed pregnancies. The overall finding suggests that during pregnancy, podophyllotoxin use might be safe, as it did not appear to be correlated with an increased risk of adverse fetal outcomes. Moreover, while prescribing podophyllotoxin, these findings might help guide clinicians, people, and drug regulatory authorities.