Zhang Y, Yu Y, Zhu J, et al. - Estimated glomerular filtration rate (eGFR) could represent a crucial risk factor in predicting as well as stratifying the risk of atherosclerotic cardiovascular disease (ASCVD). Combining eGFR into existing risk evaluation tools is recommended to enhance predictive performance.

• From 28,187 participants from Shanghai Suburban Adult Cohort and Biobank study, baseline data were utilized, and experts adopted Pooled Cohort Equations (PCEs) and Prediction for ASCVD Risk in China (China-PAR) to estimate 10-year ASCVD risk.

• A gradual increase in the median of 10-year ASCVD risk was evident with the decrease of eGFR level.

• The adjusted odds ratios, for males, of 10-year high ASCVD risk by PCEs linked with eGFR (60-74 and <60 mL/min/1.73 m ² ) were 1.52 and 2.51; the corresponding result was significant only for eGFR <60 mL/min/1.73 m ² , OR of 1.57 for females.

• When China-PAR was used, the adjusted OR of 10-year high risk related to eGFR<60 mL/min/1.73 m ² was estimated to be 1.82 (1.40-2.38) in men.

• By receiver operating characteristic, eGFR holds a good predictive value for 10-year high ASCVD risk.