Cummings SR, et al. - Through a meta-analysis of 38 randomized clinical trials involving 101,642 participants that assessed drug therapies for osteoporosis, researchers determined whether randomized clinical trials showed that treatment with bisphosphonates, especially zoledronate, was correlated with decreased mortality rates. Between all drug treatments, no important relation for osteoporosis and the overall mortality rate was evident, and no meaningful relationship between clinical trials of bisphosphonate treatment and overall mortality was noted. Moreover, clinical trials of zoledronate treatment demonstrated no relationship with the overall mortality rate, though, for heterogeneity of the results, evidence existed. Thus, bisphosphonate treatment may not be related to decreased overall mortality rates in addition to reduced fracture risk and should only be suggested to reduce fracture risk.