Vetrani C, et al. - Researchers, in this work, aim to assess whether the intake of different polyphenol subclasses is associated with clinical outcomes beneficially improved by polyphenols in a nutritional trial performed by their group (postprandial lipid response, glucose homeostasis, early insulin secretion and oxidative stress). Findings indicate that a polyphenol-rich diet might have a pleiotropic effect on cardiometabolic risk factors thanks to the specific action of different polyphenol subclasses.