Nagata C, Wada K, Yamakawa M, et al. - Dietary melatonin intake was significantly related to a reduced risk of total, cardiovascular, and non-cancer, non-cardiovascular mortality, thus demonstrating a potential benefit with regard to mortality rates.

• A population-based cohort study in Japan.

• Participants were 13,355 men and 15,724 women, aged 35 years and older.

• A food-frequency questionnaire was employed.

• Participants were observed during 16 years of follow-up.

• Follow-up revealed 5,439 deaths.

• For highest vs lowest melatonin quartile, hazard ratios were 0.90, 0.85 and 0.77 for total, cardiovascular, and non-cancer, non-cardiovascular mortality, respectively.