Boucquemont J, Pai ALH, Dharnidharka VR, et al. - Given the possible hindering effect of disruption of usual routines on adherence, increasing the risk of rejection, researchers compared weekend vs weekday medication adherence among adolescent and young adult kidney transplant recipients. They assess if poorer adherence is reported on weekends. They used data from the Teen Adherence in Kidney transplant Effectiveness of Intervention Trial for this work. Assessment of adherence was done in participants 11-24 years followed in eight transplant centers in Canada and the United States using electronic pillboxes. Taking and timing adherence were poorer on weekends than weekdays in the run-in (136 participants) and the intervention interval (taking OR = 0.74 [0.67-0.81] and timing OR = 0.71 [95% CI 0.65-0.77]). No interaction by the treatment group was observed (64 intervention and 74 control participants). Findings thus suggest that weekends disrupt regular routines, posing a threat to adherence. They recommend encouraging patients and families to generate strategies to maintain adherence when routines are disrupted.