Sagara R, Inoue T, Sonoda N, et al. - The risk of developing left ventricular diastolic dysfunction (LVDD) may be increased by elevated cortisol levels in Diabetes mellitus (DM) patients.

• Between November 2016 and March 2019, researchers recruited a total of 109 patients with DM and 104 patients without DM who underwent echocardiographic examination at Kyushu University Hospital, Japan.

• In patients with DM, multivariate linear regression analysis demonstrated that log E/eʹ was positively correlated with age (p = 0.017), log systolic blood pressure (p = 0.004), and cortisol (p = 0.037) and negatively correlated with eGFR (p = 0.016) and the usage of SGLT2 inhibitors (p = 0.042).

• Multivariate analysis exhibited that there was positive association between cortisol and age (p = 0.016), HbA1c (p = 0.011).

• No relationship was observed between E/eʹ and cortisol in patients without DM.