Matsumoto K, Jin Z, Homma S, et al. - In order to clarify the link between central blood pressure (BP) and silent cerebrovascular disease, researchers analyzed 993 participants with mean age 71.7 ± 9.3 years, including 37.9% men, in the CABL (Cardiovascular Abnormalities and Brain Lesions) study. The participants were examined via 2-dimensional echocardiography, arterial wave reflection analysis for the ascertainment of central BPs, and brain magnetic resonance imaging. Using the radial pulse waveform, they calculated central BPs. Findings revealed independent links of both brachial and central pulse pressure with silent brain infarction in a predominantly older population-based cohort. However, a significant link with white matter hyperintensity volume was displayed by higher central systolic BP and central pulse pressure, but not brachial BP.