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Association between advanced fibrosis in fatty liver disease and overall mortality based on body fat distribution

Journal of Gastroenterology and Hepatology Nov 01, 2019

Chung GE, Heo NJ, Kim D, et al. - In this prospective cohort study involving 34,080 patients (mean age was 51.4 years), researchers assessed the effect of fatty liver disease and advanced fibrosis on overall mortality with an emphasis on body size and computed tomography analyzed abdominal fat distribution. The sample consisted of patients who had abdominal ultrasonography and fat computed tomography, from 2007 to 2015. The authors discovered that fatty liver disease prevalence was 37.5%, while advanced fibrosis prevalence in the fatty liver disease was 1.8%. Two hundred ninety-six deaths occurred during a median follow-up of 87 months. Higher overall mortality was not associated with fatty liver disease, although reduced mortality was associated with increased subcutaneous adiposity. Advanced fibrosis resulted in an overall mortality increase of 3.5-fold, which in the nonobese was more pronounced.
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