Jiang L, et al. - Researchers, in this current study, examined the myelin oligodendrocyte glycoprotein (MOG) and myelin-associated glycoprotein (MAG) levels and their correlations with white matter (WM) integrity in first-episode, drug-naïve major depressive disorder (MDD) patients. In MDD patients, observations revealed two-way correlations between the MOG and MAG levels and the FA and mean diffusivity values in the WM of the left middle frontal lobe, right inferior parietal lobe, and right supplementary motor area. This study thereby provided first evidence suggesting an association of elevated serum MOG and MAG levels with disrupted white matter integrity in first-episode, drug-naive patients with MDD.