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Association analysis of interleukin-23 receptor SNPs and SAPHO syndrome in Chinese people

International Journal of Rheumatic Diseases Nov 15, 2019

Guo C, et al. - Genomic DNA was collected from 71 synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) persons and 104 healthy controls in order to assess whether the formerly reported autoimmune disease-associated single nucleotide polymorphisms had any genetic overlap with SAPHO syndrome. It was discovered that variants rs10889677, rs2201841, and rs7517847 of IL-23R, and variant rs2243248 of IL-4, exhibited strong correlations with SAPHO syndrome. Moreover, individuals carrying the A-G-C-G-T haplotype of IL-23 were significantly more inclined to develop SAPHO syndrome.
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