Heikkinen I, Bello I, Wahab A, et al. - Researchers assessed a multicenter cohort of early oral tongue squamous cell carcinoma (OTSCC) to appraise the prognostic value of tumor-infiltrating lymphocytes (TILs). The surgical resection slides stained with hematoxylin and eosin were assessed for TILs. The stromal compartment and the intraepithelial compartment were examined in the assessment of TILs (at the invasive front and at the center of the tumor). Method recently described by the International Immuno-Oncology Biomarker Working Group was used for TIL assessment. They included a total of 308 cases from the 5 Finnish university hospitals and from A.C. Camargo Cancer Center, São Paulo, Brazil. The multivariable analysis revealed a promising prognostic value for stromal TILs at the invasive front with a hazard ratio of 2.61 for overall survival, 1.99 for disease-specific survival, and 1.94 for disease-free survival. They identify evaluation of TILs as simple and valuable for identification of the high-risk cases of early OTSCC. For standardized determination of TILs in early OTSCC, the method introduced by the International Immuno-Oncology Biomarker Working Group can be used.