Wenzel M, Würnschimmel C, Chierigo F, et al. - Researchers carried out a critical appraisal of the relationship between the number of positive prostate biopsy cores and CSM in high versus very high-risk prostate cancer (PCa). They distinguished 13,836 high vs 20,359 very high-risk PCa patients within the Surveillance, Epidemiology, and End Results database (2010–2016). They investigated discrimination according to 11 different positive prostate biopsy core cut-offs in Kaplan–Meier, cumulative incidence, and multivariable Cox and competing risks regression models. It was shown that the more than or equal to 8 positive prostate biopsy cores cutoff yielded optimal results. As per the findings, it was very closely followed by more than or equal to 5 positive prostate biopsy cores. Nevertheless, based on its existing wide implementation, more than or equal to 5 positive prostate biopsy cores cutoff, might represent the optimal choice.