Shi W, et al. - This study was intended to establish a novel procedure to calculate single-kidney glomerular filtration rate (GFR) using a combination of contrast-enhanced CT and serum creatinine (SCr) values and to confirm the resulting estimated glomerular filtration rates (eGFRs) by comparing them with the single-kidney Gates GFR, which is based on renal dynamic imaging. Researchers retrospectively enrolled a total of 62 individuals with asymmetric renal disease who had undergone unenhanced and triphasic contrast-enhanced CT of the kidneys, 99mTc–diethylenetriamine pentaacetic acid renal dynamic imaging, and SCr testing within 1 week. They compared the four CT split eGFRs with the Gates GFR using the paired-sample t test, Pearson correlation analysis, and Bland-Altman analysis. Applying a combination of contrast-enhanced CT and SCr values, sSplit renal function can be estimated to calculate eGFR. The study demonstrates that the CT images of the nephrographic phase may be the optimal choice to use in this proposed technique.