Ben-Horin S, et al. - In a prospective observational cohort study, researchers assessed the accuracy, safety, and tolerability of an intensive monitoring strategy to predict Crohn's disease's future course in patients with quiescent disease, as well as evaluated the ability of the different Crohn's disease monitoring methods used to predict a flare occurrence during the 24-month follow-up period. Study participants included patients (older than 18 years) with quiescent (for 3–24 months) Crohn's disease involving the small bowel with confirmed small bowel patency from three tertiary medical centres in Israel. No future flare was predicted by any clinicodemographic parameter. Faecal calprotectin predicts short-term flare risk in patients with quiescent Crohn's disease involving the small bowel, while VCE predicts short-term and long-term disease exacerbation risk. If corroborated by additional studies, VCE protocols could expand the scope of available methods to monitor disease activity and predict outcomes in small bowel Crohn's disease.