Ben-Horin S, et al. - In patients with quiescent disease, researchers assessed the accuracy, safety, and tolerability of an intensive monitoring strategy designed to predict the future course of Crohn's disease. In addition, they evaluated the ability of the different Crohn's disease monitoring methods used to predict the occurrence of a flare during the 24-month follow-up period. The study sample consisted of patients (older than 18 years) with quiescent (for 3–24 months) Crohn's disease involving the small bowel with confirmed small bowel patency from three tertiary medical centres in Israel. No future flare was anticipated by any clinicodemographic parameter. According to this prospective observational cohort study, faecal calprotectin predicts short-term flare risk in patients with quiescent Crohn's disease involving the small bowel, while VCE predicts short-term and long-term disease exacerbation risk. If corroborated by additional studies, VCE protocols could expand the scope of available methods to monitor disease activity and predict outcomes in small bowel Crohn's disease.