Saleh HM, et al. - In this observational analytical cross-sectional pilot study involving 120 individuals, aged 18 to 30 years, researchers sought to measure serum levels of interleukin 19 (IL‐19) in acne vulgaris patients with different severities, and compare it with healthy controls, to assess its role in the pathogenesis of acne vulgaris and correlate it with acne severity. Participants were divided into four groups, 30 in each; mild, moderate, and severe AV patients groups according to acne severity as well as apparently healthy controls group of matched age and sex with no known history of acne or active acne. According to findings, IL‐19 is linked to the etiopathological inflammatory process of acne vulgaris and correlates with the severity of acne. As a prognostic inflammatory marker, it may be proposed for acne vulgaris.