Morris JC, et al. - In this cohort study involving 1,255 participants, researchers ascertained if there exist racial disparities in molecular biomarkers for Alzheimer disease. According to findings, the lower cerebrospinal fluid concentrations of total tau and phosphorylated tau₁₈₁ in African American people seem to reflect a significant race by apolipoprotein E (APOE) ε4 interaction, implying a differential impact of this Alzheimer risk variant in African American people vs white people. Investigators suggested that molecular biomarker analysis of Alzheimer's disease should be racially adjusted.