Al-Zaghal A, et al. - In this retrospective study, researchers determined the role of ¹⁸F-sodium fluoride (¹⁸F-NaF) PET/CT imaging in the assessment of physiologic molecular calcification in the intracranial structures. In addition, they investigated the association of ¹⁸F-NaF accumulation with age and Hounsfield unit (HU) in certain anatomic sites that are known to calcify with normal aging. Study participants included 78 healthy subjects from the Cardiovascular Molecular Calcification Assessed by ¹⁸F-NaF PET/CT (CAMONA) clinical trial. In several intracranial structures, ¹⁸F-NaF could be used in the assessment of physiologic calcification. Significant associations were observed between ¹⁸F-NaF uptake and aging and HU in the calcified choroid plexus and epithalamus. This investigation further supported the growing interest in using ¹⁸F-NaF to detect extraosseous, molecular calcification, and this powerful sample has potential applications for evaluating various age-related, neurodegenerative brain processes.