O’Fee K, Deych E, Ciani O, et al. - According to this meta-analysis, treatments that decrease nonfatal myocardial infarction (MI) cannot be assumed to attenuate all-cause or cardiovascular (CV) mortality.

• A meta-analysis of 144 randomized clinical trials with data from 1,211,897 patients.

• Nonfatal MI failed to meet the threshold for surrogacy for all-cause or CV mortality.

• Primary, secondary, mixed primary and secondary prevention, or revascularization trials demonstrated that nonfatal MI was not a surrogate for all-cause mortality.

• Nonfatal MI failed to be a surrogate for all-cause death, in randomized clinical trials with 2.0 to 3.9, 4.0 to 5.9, or 6.0 or more years of follow-up.