Bacchetta J, et al. - Since assessment of mineral metabolism is complex in pediatrics, therefore, among 100 healthy teenagers (10-18 years), researchers evaluated the evolution of the main mineral and bone biomarkers (total/bone alkaline phosphatase ALP/BAP, β-crosslaps, osteocalcin, sclerostin, C-terminal and intact FGF23). Multivariable analyses demonstrated that renal function and PTH were significant predictors of calciuria and urinary calcium/creatinine, whereas 25D remained a predictor only of urinary calcium/creatinine ratio. Using the latest assays, this investigation presented data for mineral/bone biomarkers across puberty and highlighted the risk of hyper-calciuria in apparent asymptomatic healthy teenagers, not associated with calcium intake but rather to 25D.