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Assessment of maternal and neonatal cord blood SARS-CoV-2 antibodies and placental transfer ratios

JAMA Pediatrics Jun 11, 2021

Flannery DD, Gouma S, Dhudasia MB, et al. - Researchers intended to determine if there is an association between maternal and neonatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific antibody concentrations. The Pennsylvania Hospital in Philadelphia, Pennsylvania, hosted this cohort study. In total, 1,714 women delivered at the study site between April 9 and August 8, 2020. Maternal IgG antibodies to SARS-CoV-2 were transferred across the placenta after asymptomatic and symptomatic infection during pregnancy in this cohort study. Cord blood antibody concentrations were found to be related to maternal antibody concentrations and with the duration between onset of infection and delivery. The findings show that maternally derived SARS-CoV-2 specific antibodies have the potential to protect neonates from coronavirus disease in 2019.

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