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Assessment of maternal and neonatal cord blood SARS-CoV-2 antibodies and placental transfer ratios

JAMA Feb 03, 2021

Flannery DD, Gouma S, Dhudasia MB, et al. - In this cohort study, researchers intended to determine if there is an association between maternal and neonatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific antibody concentrations. This investigation was carried out at Pennsylvania Hospital in Philadelphia, Pennsylvania. In total, 1,714 women delivered at the study site between April 9 and August 8, 2020. Maternal IgG antibodies to SARS-CoV-2 have been transferred across the placenta following asymptomatic and symptomatic infection during pregnancy. Cord blood antibody concentrations associated with maternal antibody concentrations and with a duration between onset of infection and delivery. The findings demonstrate the potential for maternally derived SARS-CoV-2 specific antibodies to provide neonatal protection against COVID-19.

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