• Profile
Close

Assessment of factors affecting disability in inflammatory bowel disease and the reliability of the Inflammatory Bowel Disease Disability Index

Alimentary Pharmacology and Therapeutics Evidence based | Oct 13, 2017

Lo B, et al. - This meta-analysis was performed to evaluate the severity of disability and associated factors using the Inflammatory Bowel Disease Disability Index (IBD-DI) and examine the validity of the IBD-DI as a tool. In this systematic review, the researchers found a significant relationship between disease activity, treatment received and disability, although significant heterogeneity was found. As per findings, the IBD-DI was reliable and valid. However, to measure its interpretability, further studies were required.

Methods
  • The researchers performed a systematic review of cross-sectional studies.
  • Patients who had Crohn's disease (CD) and ulcerative colitis (UC) were included and classified as active, in remission, or needing surgery, biological and/or steroid treatment.
  • Using the IBD-DI, they included studies assessing disability.
  • The studies were captured by electronic and manual searches (January 2017).
  • They evaluated the possibility of bias with the Newcastle-Ottawa Scale.

Results
  • The researchers included 9 studies with 3167 patients.
  • Patients with active disease had higher disability rates than those in remission (SMD [CI95] = 1.49[1.11, 1.88], I2 = 94%, P<.01).
  • In comparison, patients on biological treatment had lower disability rates than those receiving corticosteroid treatment (SMD [CI95] = -0.22[-0.36, -0.08], I2 = 0%, P<.01).
  • In this study, disease activity and unemployment were found to be associated factors.
  • For internal consistency, the IBD-DI scored “good”, for intra-rater reliability “fair” to “excellent” and for inter-rater reliability “excellent”.
  • Construct validity was “moderately strong” to “very strong” and structural validity was seen to be mainly unidimensional.
  • While its interpretability was only useful on a group level, the IBD-DI had excellent responsiveness.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay