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Assessment of CTNNB1 gene mutations and β-catenin immunoexpression in salivary gland pleomorphic adenomas and adenoid cystic carcinomas

Virchows Archiv Mar 30, 2018

Cavalcante RB, et al. - Experts intended to contemplate the possible CTNNB1 mutations in salivary gland pleomorphic adenomas (PAs) and adenoid cystic carcinomas (ACCs). Furthermore, they investigated the possible differences in β-catenin immunoexpression in relation to these mutations, along with the histopathological aspects of these tumors. Findings illustrated the significance of β-Catenin in the pathogenesis of salivary gland PAs and ACCs. CTNNB1 exon 3 mutations did not exert a notable impact on the β-catenin cytoplasmic/membranous expression or nuclear translocation in these tumors.

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