Zeng Y, et al. - Researchers conducted this prospective study to assess the impact of Cow’s milk-related symptom scores (CoMiSS) in early identification of cow’s milk protein allergy (CMPA) in Chinese infants. CoMiSS was calculated for 38 infants with suspected CMPA [defined as documented nutritional exposure of infants and their mothers to the protein of cow's milk plus at least one of the following conditions: (a) anaphylactic reaction (b) gastrointestinal, respiratory, or dermatologic manifestations, excluding acute infection diseases] diagnosed in the pediatric gastroenterologic clinic in the hospital. Data reported that CoMiSS's sensitivity was 87.5%, while CoMiSS's specificity was 78.6%. According to findings, CoMiSS is a simple and operable method of screening for CMPA, although the risk of under-diagnosis may exist when CoMiSS≥12 is used as the criterion for early identification of CMPA in Chinese infants. There is a need for more multi-center studies to assess whether the factors like bloody stool should be included in CoMiSS or CoMiSS≥6 can be used as the criterion for early identification of CMPA in Chinese infants.