Assessment of clinical performance of an ultrasensitive nanowire assay for detecting human papillomavirus DNA in urine
Gynecologic Oncology Mar 10, 2020
Lee HJ, et al. - Researchers investigated the potential utility of HPV (human papillomavirus) DNA in urine as an alternative biomarker for HPV-based cervical cancer screening. In this study, they included 67 HPV-positive (n = 42) and -negative (n = 25) women who had Cobas HPV test results available; the participants provided paired cervical and urine samples. Polyethyleneimine-conjugated nanowires led to the identification of high-risk strains of HPV DNA in unprocessed urine specimens with high sensitivity and specificity. Cervical cancer effectiveness can increase with non-invasive, urine-based HPV screening. HPV type-specific concordance rate of over 90% was observed between urine and cervical samples.
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