Brown JVE, et al. - A systematic review and meta-analysis were conducted to compare the accuracy of serum C-reactive protein (CRP) with that of microbiological blood culture for diagnosing late-onset infection in newborns. Researchers searched MEDLINE (1946-2019), Embase (1946-2019), and Science Citation Index (1900-2019) databases for references (any language). The study included cohort and cross-sectional studies that compared the accuracy of serum CRP levels with microbiological culture results to diagnose late-onset (>72 hours after birth) infection in newborns (any gestational age) hospitalized after birth. Researchers included 22 studies involving a total of 2,255 infants (sample size range, 11-590 infants). The data imply that measurement of serum CRP level at initial evaluation of an infant with suspected late-onset infection is unlikely to aid early diagnosis or to select infants to support further examination or treatment with antimicrobial therapy or other interventions.