Brindle R, et al. - Via a systematic review of 43 studies that incorporated 5,999 participants, researchers evaluated the efficiency and safety of antibiotic therapy for non–surgically acquired cellulitis. In only 15 studies, cellulitis was the primary diagnosis, and in other studies the median (interquartile range) proportion of patients with cellulitis was 29.7%. Overall, no evidence was discovered to support the supremacy of any one antibiotic over another, and antibiotics with activity against methicillin-resistant Staphylococcus aureus did not add an improvement. The use of intravenous antibiotics over oral antibiotics and treatment term of longer than 5 days were not evident. Therefore, only low-quality evidence was detected for the most relevant agent, route of administration, and term of treatment for patients with cellulitis and prospective trials require to use a standardized set of outcomes, like severity scoring, dosing, and term of therapy.